American Pain traces the rise and fall of twin bodybuilders from Florida who become the kingpins of the largest oxycodone trafficking network in US history. Drawing on hundreds of hours of wiretaps, undercover videos and exclusive interviews with key players in Florida’s pill mill boom, the film captures in dramatic detail the greatest drug racket to hit the Sunshine State since the cocaine cowboys of the 1980s. The big difference: this time, the suppliers aren’t some Colombian drug cartel; it’s the US pharmaceutical industry.